Biosynthesis of proteoglycans by chick limb bud chondrocytes
نویسندگان
چکیده
منابع مشابه
Cyclosporine Effects on Chick Limb Bud Mesenchyme and DNA Content
Background: Cyclosporine A (CsA) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. Many transplant recipients must take this medicine for the rest of their lives. Females in reproductive age group on prolonged CsA therapy have legitimate concerns about drug effects on pregnancy. Objective: To explore Cs...
متن کاملOxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes.
Oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. DNA damage caused by oxidative stress may trigger the activation of the nuclear enzyme, poly(ADP-ribose) polymerase-1 (PARP-1) which may contribute to tissue injury. We aimed at investigating the effects of peroxynitrite (100-600 microM) and hydrogen pero...
متن کاملRetinoic acid and chick limb bud development.
The chick limb bud is a powerful experimental system in which to study pattern formation in vertebrate embryos. Exogenously applied retinoic acid, a vitamin A derivative, can bring about changes in pattern and, on several grounds, is a good candidate for an endogenous morphogen. As such, the local concentration of retinoic acid might provide cells with information about their position in relati...
متن کاملcyclosporine effects on chick limb bud mesenchyme and dna content
background: cyclosporine a (csa) is a powerful immunosuppressive agent, which is used for the prevention of allograft rejection and for the treatment of autoimmune diseases. many transplant recipients must take this medicine for the rest of their lives. females in reproductive age group on prolonged csa therapy have legitimate concerns about drug effects on pregnancy. objective: to explore ...
متن کاملExpression of csal1 in pre limb-bud chick embryos.
The spalt family of transcriptional repressors has been implicated in limb, heart, ear and kidney development and truncating mutations in a human gene, SALL1, result in the autosomal dominant disorder Townes-Brocks syndrome. Here we show the expression pattern of the chick orthologue of the SALL1 gene, csal1, during early development. We found csal1 expression in the heart and in the pharynx, a...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1978
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)30449-0